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Carbetocin Injection

Obstetrics and Gynecology

Carbetocin Injection

Carbetocin Injection is an essential medication designed to prevent excessive bleeding after childbirth, known as postpartum hemorrhage (PPH). Acting as a synthetic analog of the naturally occurring hormone oxytocin, it effectively stimulates uterine contractions to reduce blood loss after delivery. Its targeted action and prolonged effect make it a preferred choice in managing PPH in certain clinical settings.

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    Chemical Composition: 
    Carbetocin is a long-acting oxytocin analog, modified to provide sustained uterotonic activity when administered intravenously or intramuscularly.
    Mechanism of Action: 
    It binds to oxytocin receptors in the uterine muscle, inducing rhythmic contractions which help to clamp down the uterus and prevent excessive bleeding after delivery.
    Indications and Usage: 
    Indicated primarily for the prevention of PPH following cesarean section under epidural or spinal anesthesia. Its use is recommended in settings where the risk of PPH is higher or where the management of PPH is critical.
    Administration and Dosage: 
    Carbetocin is administered as a single intravenous injection or intramuscular dose immediately after the delivery of the infant, ensuring rapid onset of action for effective management of uterine tone.
    Efficacy and Outcomes: 
    Clinical studies have shown that Carbetocin is effective in reducing the incidence of PPH, minimizing the need for additional uterotonic agents, and lowering the risk of severe postpartum hemorrhage.
    Side Effects: 
    Side effects may include nausea, vomiting, abdominal pain, headache, and hypertension. It is generally well-tolerated when used as directed.
    Contraindications and Precautions: 
    Not recommended for use during pregnancy before the delivery of the baby due to the risk of inducing premature labor. Careful monitoring is advised in patients with cardiovascular disorders.

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